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논문번호 71
논문제목(영문) Effect of stents coated with a combination of sirolimus and alpha-lipoic acid in a porcine coronary restenosis model.
국내외구분 국외 SCI여부 SCI(E)
연구책임자역할 교신저자
주저자명 Lim KS, Park JK
교신저자명 Jeong MH
공동저자명 Lim KS, Park JK, Jeong MH, Bae IH, Nah JW, Park DS, Kim JM, Kim JH, Lee SY, Jang EJ, Jang S, Kim HK, Sim DS, Park KH, Hong YJ, Ahn Y, Kang JC;
게제년월일 2016-04-01
ISSN 0957-4530
Impact Factor 2.587
학술지명 Journal of materials science. Materials in medicine
서지사항 0집 / 27권 / 4호,   페이지(66 - 76)
요약초록문
(Abstract) 입력		 The aim of this study was to evaluate antiproliferative sirolimus- and antioxidative alpha-lipoic acid (ALA)-eluting stents using biodegradable polymer [poly-L-lactic acid (PLA)] in a porcine coronary overstretch restenosis model. Forty coronary arteries of 20 pigs were randomized into four groups in which the coronary arteries had a bare metal stent (BMS, n = 10), ALA-eluting stent with PLA (AES, n = 10), sirolimus-eluting stent with PLA (SES, n = 10), or sirolimus- and ALA-eluting stent with PLA (SAS, n = 10). A histopathological analysis was performed 28 days after the stenting. The ALA and sirolimus released slowly over 30 days. There were no significant differences between groups in the injury or inflammation score; however, there were significant differences in the percent area of stenosis (56.2 ± 11.78 % in BMS vs. 51.5 ± 12.20 % in AES vs. 34.7 ± 7.23 % in SES vs. 28.7 ± 7.30 % in SAS, P < 0.0001) and fibrin score [1.0 (range 1.0-1.0) in BMS vs. 1.0 (range 1.0-1.0) in AES vs. 2.0 (range 2.0-2.0) in SES vs. 2.0 (range 2.0-2.0) in SAS, P < 0.0001] between the four groups. The percent area of stenosis based on micro-computed tomography corresponded with the restenosis rates based on histopathological stenosis in different proportions in the four groups (54.8 ± 7.88 % in BMS vs. 50.4 ± 14.87 % in AES vs. 34.5 ± 7.22 % in SES vs. 28.9 ± 7.22 % in SAS, P < 0.05). SAS showed a better neointimal inhibitory effect than BMS, AES, and SES at 1 month after stenting in a porcine coronary restenosis model. Therefore, SAS with PLA can be a useful drug combination for coronary stent coating to suppress neointimal hyperplasia.
파일  B71.+J+Mater+Sci+Mater+Med.+2016;27(4)66-76. (1).pdf (2.6M) DATE : 2021-05-21 11:23:16