비임상

HOME > 연구실적 > 비임상 > 논문
 
작성일 : 18-05-28 10:54
논문번호 84
논문제목(영문) Long-term preclinical evaluation of bioabsorbable polymer-coated drug-eluting stent in a porcine model.
국내외구분 국내 SCI여부 SCI(E)
연구책임자역할 교신저자
주저자명 Lim KS, Park JK
교신저자명 Jeong MH
공동저자명 Lim KS, Park JK, Lim KS, Park JK, Nah JW, Bae IH, Park DS, Shim JW, Kim JH, Kim HK, Kim SS, Sim DS, Hong YJ, Kim JH, Ahn Y
게제년월일 2017-07-01
ISSN 1598-5032
Impact Factor 1.405
학술지명 Macromolecular Research
서지사항 1집 / 25권 / 7호,   페이지(730 - 738)
요약초록문
(Abstract) 입력		 Bioabsorbable polymer-based drug-eluting stents have been shown to be effective and safe in the actual practice. The objective of the present study was to evaluate a biodegradable poly-L-lactic acid (PLLA)-based sirolimus-coated stent in comparison with a commercial everolimus-eluting stent with a permanent polymer in a porcine coronary restenosis model on a short-, mid-, and long-term basis. Pigs were randomized into eight groups in which the coronary arteries (36 pigs with 72 coronary arteries) had either a sirolimus-eluting stent with PLLA (SES, n=24, follow-up after 4, 12, and 24 weeks), bare metal stent (BMS, n=12, follow-up after 4 weeks), PLLA-coated stent without a drug (PCS, n=12, follow-up after 4 weeks), or commercial everolimus-eluting stent with a permanent polymer (EES, Promus PREMIER®, n=24, follow-up after 4, 12, and 24 weeks). Histopathological analysis was performed at 4, 12, or 24 weeks after stenting. The surface morphology of the SES, visualized using an optical microscope and a scanning electron microscope, was smooth and uniform with virtually no defects. Sirolimus was released slowly over 60 days. There was no significant difference in the percent area stenosis between the SES and EES at any of the follow-up time points (13.0±8.10% in SES vs. 14.1±9.12% in EES at 4 weeks, 23.1±8.63% in SES vs. 21.3±7.92% in EES at 12 weeks, 28.2±8.20% in SES vs. 25.1±8.51% in EES at 24 weeks, each p=NS). The percent area stenosis using micro-computed tomography and intravenous ultrasound demonstrated similar restenosis rates with histopathological stenosis between the SES and EES. The SES with a biodegradable polymer was as effective as the commercial EES with a permanent polymer in inhibiting neointima proliferation at 4, 12, and 24 weeks in a porcine coronary restenosis model.
파일  84-Long-term preclinical evaluation of bioabsorbable polymer-coated drug-eluting stent in a porcine model..pdf (6.8M) DATE : 2018-05-28 10:54:21