비임상

HOME > 연구실적 > 비임상 > 논문
 
작성일 : 18-05-28 10:59
논문번호 85
논문제목(영문) Evaluation of ion implantation for anti-thrombogenic coronary stent in vitro and in vivo.
국내외구분 국외 SCI여부 SCI(E)
연구책임자역할 교신저자
주저자명 Shim JW, Bae IH
교신저자명 Jeong MH
공동저자명 Shim JW, Bae IH, Park DS, Lim KS, Lee SY, Jang EJ, Park JK, Kim JH, Jeong MH
게제년월일 2017-10-25
ISSN 1226-086X
Impact Factor 4.421
학술지명 Journal of Industrial and Engineering Chemistry
서지사항 1집 / 54권 / 1호,   페이지(290 - 297)
요약초록문
(Abstract) 입력		 The aim of this study was to evaluate the effect of ion implantation on the surface of anti-thrombogenic coronary stent. Nitrogen (N) was implanted into the cobalt–chromium surface by using an ion source under a plasma environment to enhance its hardness and surface modification. The N ion dosage was 1 × 1015 ions/cm2. All analysis results of the ion implanted stent were compared with those of bare metal stent. The N component and distribution were confirmed by auger electron spectroscopy. Microhardness was significantly increased after 40 min of implantation (415.3 ± 12.38 HV, 18.9 ± 2.62%). The surface was altered to hydrophobic status through ion implantation (30.6 ± 1.12% in contact angle increment). Platelet adhesion, and smooth muscle cell migration and proliferation were prevented in the ion implanted group (43.9%, 11.2%, and 45.1%, respectively). To verify the in vitro result, stents were implanted to rabbit iliac artery and isolated at 4 weeks post implantation. Then, the stents were subjected to histological analysis. No significant differences in injury score, internal elastic lamina, lumen area, and restenosis rate were found. However, the fibrin score was more significantly decreased in the ion beam-implanted group (2.5 ± 0.15) than in the bare metal stent group (1.8 ± 0.31, n = 10, p < 0.05). Taken together, ion beam implantation may be an efficient accessorial tool for preventing in-stent restenosis and in-stent thrombosis.
파일  85-Evaluation of ion implantation for anti-thrombogenic coronary stent in vitro and in vivo..pdf (2.0M) DATE : 2018-05-28 10:59:56