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작성일 : 18-05-28 11:24
논문번호 90
논문제목(영문) Novel Polymer-Free Everolimus-Eluting Stent Fabricated using Femtosecond Laser Improves Re-endothelialization and Anti-inflammation
국내외구분 국외 SCI여부 SCI(E)
연구책임자역할 교신저자
주저자명 Bae IH
교신저자명 Jeong MH
공동저자명 Bae IH, Jeong MH, Lim KS, Park DS, Shim JW, Park JK, Oh KH, Jin MR, Sim DS.
게제년월일 2018-05-09
ISSN 2045-2322
Impact Factor 4.259
학술지명 Scientific reports
서지사항 0집 / 8권 / 1호,   페이지(7383 - 7394)
요약초록문
(Abstract) 입력		 The aim of this study was to fabricate a novel polymer-free everolimus-eluting stent with nanostructure using a femtosecond laser (FSL). The stent were coated with everolimus (EVL) using FSL and electrospinning processes. The surface was rendered hydrophobic, which negatively affected both platelet adhesion (82.1%) and smooth muscle cell response. Animal study was performed using a porcine coronary restenosis model. The study groups were divided into 1) bare metal stent (BMS), 2) poly(L-lactide) (PLA)-based EVL drug eluting stent (DES), 3) commercial EVL-eluting DES, and 4) FSL-EVL-DES. After four weeks of stent implantation, various analyses were performed. Quantitative analysis showed that the amount of in-stent restenosis was higher in the BMS group (BMS; 27.8 ± 2.68%, PLA-based DES; 12.2 ± 0.57%, commercial DES; 9.8 ± 0.28%, and FSL-DES; 9.3 ± 0.25%, n = 10, p < 0.05). Specifically, the inflammation score was reduced in the FSL-DES group (1.9 ± 0.39, n = 10, p < 0.05). The increment in re-endothelialization in the FSL-DES group was confirmed by immunofluorescence analysis. Taken together, the novel polymer-free EVL-eluting stent fabricated using FSL can be an innovative DES with reduced risk of ISR, thrombosis, and inflammation.
파일  90-Novel Polymer-Free Everolimus-Eluting Stent Fabricated using Femtosecond Laser Improves Re-endothelialization and Anti-inflammation.pdf (4.1M) DATE : 2018-05-28 11:24:06