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논문번호 91
논문제목(영문) Modified Magnesium Hydroxide Nanoparticles Inhibit the Inflammatory Response to Biodegradable Poly(lactide-co-glycolide) Implants
국내외구분 국외 SCI여부 SCI(E)
연구책임자역할 공저자
주저자명 Lih E
교신저자명 Han DK
공동저자명 Lih E, Kum CH, Park W, Chun SY, Cho Y, Joung YK, Park KS, Hong YJ, Ahn DJ, Kim BS, Kwon TG, Jeong MH, Hubbell JA, Han DK
게제년월일 2018-05-29
ISSN 1936-0851
Impact Factor 13.903
학술지명 ACS Nano
서지사항 0집 / 12권 / 7호,   페이지(6917 - 6925)
요약초록문
(Abstract) 입력		 Biodegradable polymers have been extensively used in biomedical applications, ranging from regenerative medicine to medical devices. However, the acidic byproducts resulting from degradation can generate vigorous inflammatory reactions, often leading to clinical failure. We present an approach to prevent acid-induced inflammatory responses associated with biodegradable polymers, here poly(lactide-co-glycolide), by using oligo(lactide)-grafted magnesium hydroxide (Mg(OH)2) nanoparticles, which neutralize the acidic environment. In particular, we demonstrated that incorporating the modified Mg(OH)2 nanoparticles within degradable coatings on drug-eluting arterial stents efficiently attenuates the inflammatory response and in-stent intimal thickening by more than 97 and 60%, respectively, in the porcine coronary artery, compared with that of drug-eluting stent control. We also observed that decreased inflammation allows better reconstruction of mouse renal glomeruli in a kidney tissue regeneration model. Such modified Mg(OH)2 nanoparticles may be useful to extend the applicability and improve clinical success of biodegradable devices used in various biomedical fields.
파일  91. Modified Magnesium Hydroxide Nanoparticles.pdf (8.7M) DATE : 2024-08-05 15:50:56