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논문번호 28
논문제목(영문) Re-endothelization and Inflammatory Reaction at Site of Overlapping Drug-Eluting Stents in a Porcine Coronary In-Stent Restenosis Model.
국내외구분 국내 SCI여부 SCI(E)
연구책임자역할 교신저자
주저자명 Lim SY
교신저자명 Jeong MH
공동저자명 Lim SY, Jeong MH, Kim JH, Lee SR, Moon JY, Hong YJ, Kim JH, Ahn Y, Cho JG, Park JC, Kim KS, Joo SJ, Kang JC;
게제년월일 2007-01-17
ISSN 1738-5520
Impact Factor 0.753
학술지명 Korean Circulation J
서지사항 0집 / 37권 / 1호,   페이지(33 - 38)
요약초록문
(Abstract) 입력		 Background and Objectives：This study was conducted to evaluate the inflammatory reaction at sites of overlapping stents in a porcine in-stent restenosis (ISR) model.
Materials and Methods：Twenty bare metal stents (BMS, Group I; n=10), 20 sirolimus-eluting stents (SES, Group II; n=10), 20 paclitaxel-eluting stents (PES, Group III; n=10), 10 PESs and 10 SESs (Group IV; n=10) were deployed and overlapped in the left anterior descending coronary arteries of 40 pigs. Follow-up coronary angiograms and histopathologic analysis were performed at 4 weeks after stenting.
Results：The minimal luminal diameter of the overlapped segment at 4 weeks was smaller in group I than that in the other groups (1.78±0.13 mm vs. 2.79±0.09 mm vs. 2.90±0.04 mm vs. 2.80±0.07 mm, respectively, p<0.001). The neointimal area (5.51±0.58 mm2 vs. 2.38±0.53 mm2 vs. 2.07±0.37 mm2 vs. 2.39±0.58 mm2, respectively, p<0.001) and the area stenosis (68.74±4.02% vs. 27.79±4.73% vs. 23.66±3.24% vs. 27.63±4.07%, respectively, p<0.001) of the overlapped segment were significantly higher in Group I than that in the other groups. The inflammatory score of the overlapped segment was significantly higher in Group III than that in the other groups (1.80±0.42 vs. 2.10±0.32 vs. 2.90±0.31 vs. 2.50±0.52, respectively, p<0.001). The endothelization score of the overlapped segment was significantly lower in Group III than that in the other groups (2.80±0.42 vs. 2.30±0.67 vs. 1.30±0.48 vs. 2.10±0.74, respectively, p<0.001).
Conclusion：Compared with the BMS, the DES inhibits neointimal hyperplasia, but inflammation and poor endothelization are observed at the sites of overlapped stents.
파일  B28. Korean Circulation J 2007;37(1)33-38..pdf (1.2M) DATE : 2016-03-13 08:10:00