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논문번호 29
논문제목(영문) Inflammation and delayed endothelization with overlapping drug-eluting stents in a porcine model of in-stent restenosis.
국내외구분 국외 SCI여부 SCI(E)
연구책임자역할 교신저자
주저자명 Lim SY
교신저자명 Jeong MH
공동저자명 Lim SY, Jeong MH, Hong SJ, Lim DS, Moon JY, Hong YJ, Kim JH, Ahn Y, Kang JC;
게제년월일 2007-10-29
ISSN 1346-9843
Impact Factor 3.940
학술지명 Circulation journal
서지사항 0집 / 72권 / 3호,   페이지(463 - 468)
요약초록문
(Abstract) 입력		 BACKGROUND:
This study evaluated the inflammatory reaction at the site of overlapping drug-eluting stents (DES) in a porcine model of in-stent restenosis.
METHODS AND RESULTS:
Twenty bare metal stents (BMS) (group I; n=10), 20 sirolimus-eluting stents (SES) (group II: n=10), 20 paclitaxel-eluting stent (PES) (group III: n=10), and 10 PES and 10 SES (group IV: n=10) were overlapped in the left anterior descending coronary arteries of 40 pigs. Follow-up coronary angiography and histopathology were performed at 4 weeks after stenting. For the overlapped segments, the minimal luminal diameter at 4 weeks was smaller in group I than in the other groups (1.78+/-0.13 mm, 2.79+/-0.09 mm, 2.90+/-0.04 mm, 2.80+/-0.07 mm, respectively; p<0.001), and the neointimal area (5.51+/-0.58 mm2, 2.38+/-0.53 mm2, 2.07+/-0.37 mm2, 2.39+/-0.58 mm2, respectively; p<0.001) and area stenosis (68.74+/-4.02%, 27.79+/-4.73%, 23.66+/-3.24%, 27.63+/-4.07%, respectively; p<0.001) were higher in group I than in the other groups; however, the inflammatory score was higher in group III than in the other groups (1.80+/-0.42, 2.10+/-0.32, 2.90+/-0.31, 2.50+/-0.52, respectively; p<0.001) and the endothelization score was lower in group III than in the other groups (2.80+/-0.42, 2.30+/-0.67, 1.30+/-0.48, 2.10+/-0.74, respectively; p<0.001).
CONCLUSION:
Compared with BMS, DES inhibit neointimal hyperplasia, but inflammation and poor endothelization occur at the site of overlapping stents.
파일  B29. Circ J. 2008;72(3)463-468..pdf (418.0K) DATE : 2016-03-13 08:16:15