비임상

HOME > 연구실적 > 비임상 > 논문
 
작성일 : 16-03-13 08:41
논문번호 32
논문제목(영문) The Inhibitory Effect of Double Coating with Echinomycin and Hydrophobic Heparin in Porcine Coronary In-Stent Restenosis Model.
국내외구분 국내 SCI여부 KCI
연구책임자역할 교신저자
주저자명 Lim SY
교신저자명 Jeong MH
공동저자명 Lim SY, Jeong MH, Sim DS, Hong YJ, Kim JH. Ahn Y, Cho JG, Park JC, Kang JC, Moon HT, Byun Y;
게제년월일 2009-04-29
ISSN 2233-7385
Impact Factor 0
학술지명 Chonnam Medical Journal
서지사항 0집 / 45권 / 2호,   페이지(87 - 91)
요약초록문
(Abstract) 입력		 Stent thrombosis and in-stent restenosis are still major limitations of coronary stenting. Here, we report on a new type of drug-eluting stent (DES) aimed to prevent restenosis and thrombosis. The DES was prepared by coating a bare metal stent with echinomycin (an anti-proliferative drug) and hydrophobic heparin. The echinomycin-hydrophobic heparin double-coating stents were compared with control stents in a porcine coronary stent restenosis model. Stent overdilation injury (stent : artery＝1.1 : 1.0) was compared in porcine coronary arteries between 4 groups: bare stent group (Group I, n=3), 1% echinomycin-heparin coating stent group (Group II, n=3), 5% echinomycin-heparin coating stent group (Group III, n=3), and 10% echinomycin-heparin coating stent group (Group IV, n=3). Follow-up quantitative coronary angiography was performed 4 weeks after the stents were inserted. The histopathologic assessments of the stented porcine coronary arteries were compared between the 4 groups. The neointimal areas of the stented arteries were 4.3±1.3 mm2 in Group I, 5.7±1.3 mm2 in Group II, 3.7±1.0 mm2 in Group III, and 2.7±1.1 mm2 in Group IV; the neointimal area was significantly larger in Group II than in the other groups (p＜0.001). The histopathologic areas of stenosis were 61.4±18.1% in Group I, 79.8±24.0% in Group II, 52.0±18.5% in Group III, and 30.9±14.6% in Group IV; the histopathologic area was significantly smaller in Group IV than in the other groups (p＜0.001). In conclusion, echinomycin-hydrophobic heparin double-coating stents effectively inhibit neointimal proliferation at a relatively high level.
파일  B32. Chonnam Med J 2009;45(2)87-91..pdf (1.3M) DATE : 2016-03-13 08:41:08