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논문번호 35
논문제목(영문) Preparation of a Drug-eluting Stent Using a TiO2 Film Deposited by Plasma Enhanced Chemical Vapour Deposition as a Drug-combining Matrix.
국내외구분 국외 SCI여부 SCI(E)
연구책임자역할 공저자
주저자명 Song SJ
교신저자명 Cho DL
공동저자명 Song SJ, Park YJ, Park J, Cho MD, Kim JH, Jeong MH, Kim YS, Cho DL;
게제년월일 2010-03-17
ISSN 0959-9428
Impact Factor 6.626
학술지명 Journal of Materials Chemistry
서지사항 0집 / 20권 / 23호,   페이지(4792 - 4801)
요약초록문
(Abstract) 입력		 A TiO2 thin film was deposited onto a bare metal stent by the plasma enhanced chemical vapour deposition (PECVD) process and its potential as a drug-combining matrix was investigated. When deposited at a discharge power of 5 W, the film showed a highly smooth surface with a surface roughness of 9.4 nm, mechanical stability with good adhesion, and good blood compatibility. The film was surface-modified with water plasma to introduce hydroxyl groups on the TiO2 surface. Then, drugs could be chemically grafted to the modified surface through the formation of ester bonds between hydroxyl groups on the modified TiO2 film and carboxyl groups in the drugs. When heparin, a-lipoic acid, and abciximab were grafted onto the TiO2-deposited and surface-modified stents, the grafted amount was measured to be 106.1 mg for a-lipoic acid, 32.5 mg for abciximab, and 53.9 mg for heparin on average. In the in vitro drug-release test, heparin and abciximab were released continuously for 4 weeks but ALA showed a burst release within 6 days.
파일  B35. J. Mater. Chem., 2010;20(23)4792-4801..pdf (349.4K) DATE : 2016-03-13 08:56:22