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논문번호 40
논문제목(영문) Nitrogen-doped TiO2 films as drug-binding matrices for the preparation of drug-eluting stents.
국내외구분 국외 SCI여부 SCI(E)
연구책임자역할 공저자
주저자명 Song SJ
교신저자명 Cho DL
공동저자명 Song SJ, Jung KW, Park YJ, Park J, Cho MK, Jeong MK, Kim YS and Cho DL;
게제년월일 2011-05-25
ISSN 0959-9428
Impact Factor 6.626
학술지명 Journal of Materials Chemistry
서지사항 0집 / 21권 / 22호,   페이지(8169 - 8177)
요약초록문
(Abstract) 입력		 Abstract: Nitrogen doped-TiO2 thin film was deposited by plasma enhanced chemical vapour deposition (PECVD) process and its applicability as a drug-binding matrix was investigated in the preparation of drug eluting stents. N–TiO2 film was deposited at 5 W and uniformly covered metallic stent surfaces. Films showed excellent mechanical stability and good adhesion. Alpha lipoic acid, heparin, and abciximab could then be grafted onto the N–TiO2 film through ester bond formation after water plasma modification of the films’ surfaces. Drug-grafted N–TiO2 films showed smooth surfaces and good blood compatibility in in vitro platelet adhesion tests. The films maintained uniform coverings, without peeling, even after expansion by a balloon catheter. Grafted-heparin and abciximab could be released continuously for three weeks from drug-grafted N–TiO2 stents in in vitro drug release test. Such immunosuppressive and antiproliferative drug-grafted N–TiO2 film is expected to minimize potential problems related to organic polymers and the risk of direct contact of a bare metal surface with a blood vessel. Hence, the N–TiO2 films prepared in this study are promising alternatives to organic polymers for the preparation of drug-eluting stents.
파일  B40. J. Mater. Chem. 2011;21(22)8169-8177..pdf (331.0K) DATE : 2016-03-13 09:17:00