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논문번호 41
논문제목(영문) Effects of Ramiprilat-Coated Stents on Neointimal Hyperplasia, Inflammation, and Arterial Healing in a Porcine Coronary Restenosis Model.
국내외구분 국내 SCI여부 SCI(E)
연구책임자역할 교신저자
주저자명 Hong YJ
교신저자명 Jeong MH
공동저자명 Hong YJ, Jeong MH, Song SJ, Sim DS, Kim JH, Lim KS, Hachinohe D, Ahmed K, Hwang SH, Lee MG, Ko JS, Park KH, Yoon HJ, Yoon NS, Kim KH, Park HW, Kim JH, Ahn Y, Cho JG, Cho DL, Park JC, Kang JC;
게제년월일 2011-02-22
ISSN 1738-5520
Impact Factor 0.753
학술지명 Korean circulation journal.
서지사항 0집 / 41권 / 9호,   페이지(535 - 541)
요약초록문
(Abstract) 입력		 Abstract: BACKGROUND AND OBJECTIVES: The renin-angiotensin-aldosterone system has been implicated in the pathogenesis of neointimal hyperplasia, and a role for angiotensin II in the migration and proliferation of vascular smooth muscle cells in restenotic lesions has been proposed. The aim of this study was to determine the anti-proliferative and anti-inflammatory effects of ramiprilat-coated stents in a porcine coronary overstretch restenosis model.
SUBJECTS AND METHODS: Pigs were randomized into two groups in which the coronary arteries {16 pigs (16 coronaries in each group)} had a 3.0×17 mm
ramiprilat-coated MAC stent or a 3.0×17 mm control MAC stent (AMG, Munich,
Germany) implanted with oversizing (stent-to-artery ratio, 1.3 : 1) in porcine
coronary arteries, and histopathologic analysis was assessed 28 days after
stenting.
RESULTS: There were no significant differences in the injury and inflammation
scores between the two groups (1.20±0.43 vs. 1.23±0.57, p=0.8; and 1.21±0.39 vs. 1.25±0.49, p=0.6, respectively). Within the neointima, most inflammatory cells were lymphohistiocytes. Significant positive correlations existed between
inflammatory cell counts and the neointima areas (r=0.567, p<0.001), and between inflammatory cell counts and the percent area stenosis (r=0.478, p<0.001). There was no significant difference in the inflammatory cell counts normalized to the injury (110±89 vs. 123±83, p=0.4) and fibrin scores (0.15±0.06 vs. 0.17±0.07, p=0.8) between the 2 groups. There were trends toward a smaller neointima area (1.06±0.51 mm(2) vs. 1.28±0.35 mm(2), p=0.083) and a smaller percent area stenosis (18.9±8.7% vs. 21.8±7.2%, p=0.088) in the ramiprilat-coated stent group.
CONCLUSION: Although the ramiprilat-coated stent did not show significant
inhibitory effects on neointimal hyperplasia, the ramiprilat-coated stent showed
good effects on the inflammatory reaction and arterial healing similar to the
control stent in a porcine coronary restenosis model.
파일  B41. Korean Circ J. 2011;41(9)535-541..pdf (1.3M) DATE : 2016-03-13 09:19:38