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논문번호 55
논문제목(영문) Histopathological Comparison among Biolimus, Zotarolimus and Everolimus-Eluting Stents in Porcine Coronary Restenosis Model.
국내외구분 국내 SCI여부 SCI(E)
연구책임자역할 교신저자
주저자명 Lim KS
교신저자명 Jeong MH
공동저자명 Lim KS, Jeong MH, Bae IH, Park DS, Kim JM, Kim JH, Cho DL, Sim DS, Park KH, Hong YJ, Ahn Y;
게제년월일 2013-10-01
ISSN 1738-55220
Impact Factor 0.753
학술지명 Korean circulation journal
서지사항 0집 / 43권 / 11호,   페이지(744 - 751)
요약초록문
(Abstract) 입력		 BACKGROUND AND OBJECTIVES:
The aim of this study was to examine the histolopathogical effects among the biolimus, zotarolimus, and everolimus eluting stent (EES) in the porcine coronary restenosis model.
SUBJECTS AND METHODS:
Pigs were randomized into three groups in which the coronary arteries (15 pigs, 10 coronaries in each group) had either a biolimus A9 eluting stent (BES, n=10), zotarolimus eluting stent (ZES, n=10) or an EES (n=10). Histopathologic analysis was performed at 28 days after stenting.
RESULTS:
There were no significant differences in the injury score among the three groups. There was a significant difference in the internal elastic lamina, lumen area, neointima area, percent area stenosis, and the fibrin and inflammation score among the three groups (4.3±0.53 mm(2), 2.5±0.93 mm(2), 1.8±1.03 mm(2), 40.7±20.80%, 1.7±0.41, 1.4±0.72 in the BES group vs. 5.1±0.55 mm(2), 2.3±1.14 mm(2), 2.8±1.00 mm(2), 55.4±21.23%, 2.0±0.39, 1.6±0.76 in the ZES group vs. 4.4±0.53 mm(2), 1.7±1.22 mm(2), 2.8±1.23 mm(2), 64.0±26.00%, 1.8±0.76, 2.1±0.90 in the EES group, respectively). BES is more effective in inhibiting neointimal hyperplasia compared to ZES and EES (p<0.0001). According to the fibrin and inflammation score, BES and EES are more effective in decreasing the fibrin deposition compared to ZES (p<0.001). Moreover, BES and ZES are more effective in reducing the inflammatory reaction compared to EES (p<0.001).
CONCLUSION:
The result demonstrates that BES shows better histopathological characteristics than ZES and EES at one month after stenting in the porcine coronary restenosis model.
파일  B55. Korean Circ J. 2013;43(11)744-751..pdf (4.9M) DATE : 2016-03-13 10:24:56