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논문번호 56
논문제목(영문) Effect of atorvastatin-eluting stents in a rabbit iliac artery restenosis model.
국내외구분 국내 SCI여부 KCI
연구책임자역할 교신저자
주저자명 Lim KS
교신저자명 Jeong MH
공동저자명 Lim KS, Jeong MH, Bae IH, Park JK, Park DS, Kim JM, Kim JH, Cho DL, Sim DS, Park KH, Hong YJ, Ahn Y;
게제년월일 2013-11-01
ISSN 2233-7385
Impact Factor 0
학술지명 Chonnam medical journal
서지사항 0집 / 49권 / 3호,   페이지(118 - 124)
요약초록문
(Abstract) 입력		 Statins have pleiotropic effects, which include the inhibition of neointima hyperplasia, the inhibition of vascular inflammation, and platelet inhibition. The aim of this study was to examine the effect of an atorvastatin-eluting stent (AES) in a rabbit iliac artery overstretch restenosis model. Ten rabbits were used in this study (10 rabbits, 10 iliac arteries for each stent). An AES and paclitaxel-eluting stent (PES) were implanted in the left and right iliac arteries in a rabbit (2 stents in each rabbit). The stents were deployed with oversizing (stent/artery ratio 1.3:1), and histopathologic analysis was assessed at 28 days after stenting. There were no significant differences in the injury score, lumen area, or inflammation score. There were significant differences in the neointimal area (0.7±0.18 mm(2) in the AES group vs. 0.4±0.25 mm(2) in the PES group, p<0.01), in the percentage stenosis area (14.8±5.06% in the AES group vs. 10.5±6.80% in the PES group, p<0.05), and in the fibrin score (0.4±0.51 in the AES group vs. 2.7±0.48 in the PES group, p<0.001). Although the AES did not suppress neointimal hyperplasia compared with the PES, it showed a superior arterial healing effect in a rabbit iliac artery overstretch restenosis model.
파일  B56. Chonnam Med J. 2013;49(3)118-124..pdf (5.4M) DATE : 2016-03-13 10:26:53