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논문번호 63
논문제목(영문) Effect of pretreatment of ezetimibe/simvastatin on arterial healing and endothelialization after drug-eluting stent implantation in a porcine coronary restenosis model.
국내외구분 국내 SCI여부 SCI(E)
연구책임자역할 교신저자
주저자명 Sim DS
교신저자명 Jeong MH
공동저자명 Sim DS, Jeong MH, Park DS, Kim JH, Lim KS, Kim HK, Kim SS, Cho JY, Jeong HC, Park KH, Hong YJ, Kim JH, Ahn Y, Cho JG, Park JC;
게제년월일 2014-12-29
ISSN 1738-5520
Impact Factor 0.753
학술지명 Korean circulation journal
서지사항 0집 / 45권 / 2호,   페이지(110 - 116)
요약초록문
(Abstract) 입력		 BACKGROUND AND OBJECTIVES:
We sought to evaluate the effect of the early use of ezetimibe/simvastatin (Vytorin®) on arterial healing and endothelialization after the implantation of a drug-eluting stent (DES) in a porcine model of coronary restenosis.
MATERIALS AND METHODS:
A total of 20 pigs (40 coronary arteries) were randomly allocated to a pretreatment or no treatment group. The pretreatment group (n=20) received oral ezetimibe/simvastatin (10/20 mg) daily for 7 days before stenting and the no pretreatment group (n=20) did not. All pigs were treated with ezetimibe/simvastatin (10/20 mg) daily after stenting for 4 weeks. Stenting was performed using a bare-metal stent (BMS, n=10) and three types of DES: biolimus A9-eluting stent (BES, n=10), zotarolimus-eluting stent (ZES, n=10), and everolimus-eluting stents (EES, n=10). Four weeks later, pigs underwent a follow-up coronary angiography and were sacrificed for histopathologic analysis.
RESULTS:
There were no significant differences between the pretreatment and no pretreatment groups in the internal elastic lamina area, lumen area, neointima area, stenotic area, injury score, fibrin score, and inflammation score. In both groups, the fibrin score was higher in pigs with DES than in BMS, particularly in ZES and EES. The inflammatory score was not different between DES and BMS.
CONCLUSION:
In a porcine model of coronary restenosis, pretreatment with ezetimibe/simvastatin before DES implantation failed to improve arterial healing and endothelialization compared to treatment after stenting.
파일  B63.+Korean+Circ+J.+2015;45(2)110-116. (2).pdf (1.8M) DATE : 2021-05-21 11:18:00