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작성일 : 17-01-25 18:11
논문번호 80
논문제목(영문) Effect of Stents Coated with Artemisinin or Dihydroartemisinin in a Porcine Coronary Restenosis Model
국내외구분 국내 SCI여부 SCI(E)
연구책임자역할 교신저자
주저자명 Suyoung Jang
교신저자명 Myung Ho Jeong
공동저자명 Suyoung Jang, Myung Ho Jeong, Kyung Seob Lim, In Ho Bae, Jun-Kyu Park, Dae Sung Park, Jae Won Shim, Jung Ha Kim, Hyun Kuk Kim, Doo Sun Sim, Young Joon Hong, Youngkeun Ahn
게제년월일 2017-01-02
ISSN 1738-5520
Impact Factor 0.706
학술지명 Korean Circulation Journal
서지사항 0집 / 47권 / 1호,   페이지(115 - 122)
요약초록문
(Abstract) 입력		 Background and Objectives

Artemisinin and dihydroartemisinin are drugs used to treat malaria. These drugs suppress inflammatory reactions. The aim of this study was to examine the anti-intima hyperplasia effect of a novel drug-eluting stent with artemisinin or dihydroartemisinin in a porcine coronary restenosis model.

Materials and Methods

Pigs were randomized into four groups; in the first, the coronary arteries (20 pigs, a total of 40 coronary arteries, with 10 coronary arteries in each group) was implanted with bare metal stents (BMS, n=10); the second group was given polymer-coated stents (PCS, n=10); the third group was treated with artemisinin-eluting stents (AES, n=10); and the fourth group was given dihydroartemisinin-eluting stents (DAES, n=10). Histopathologic analysis was performed 28 days after stenting.

Results

The injury and fibrin scores among the four groups were not significantly different. However, the internal elastic lamina, lumen area, and neointima area were significantly different. Moreover, the percent area of stenosis (46.2±18.66% in BMS vs. 89.4±10.92% in PCS vs. 83.3±17.07% in AES vs. 36.7±11.20% in DAES, p<0.0001) and inflammation score (1.0 [range: 1.0-1.0] vs. 3.0 [range: 2.25-3.0] vs. 3.0 [range: 1.0-3.0] vs. 2.0 [range: 1.75-3.0] in BMS, PCS, AES, and DAES, respectively; p<0.001) were markedly decreased in the DAES group compared to the PCS group.

Conclusion

DES, which uses a natural substance, dihydroartemisinin, showed a neointima and inflammatory suppressive effect in a porcine coronary restenosis model.
파일  B80.Effect+of+Stents+Coated+with+Artemisinin+or+Dihydroartemisinin+in+a+Porcine+Coronary+Restenosis+Model.pdf (1.7M) DATE : 2021-05-21 11:34:06