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작성일 : 21-05-27 16:14
논문번호 100
논문제목(영문) Fabrication and Evaluation of Polyelectrolyte Complexes of Dextran Derivatives for Drug Coating of Coronary Stents
국내외구분 국내 SCI여부 KCI
연구책임자역할 교신저자
주저자명 Eun-Jae Jang
교신저자명 Myung Ho Jeong
공동저자명 Eun-Jae Jang, So-Youn Lee, In-Ho Bae, Dae Sung Park, Myung Ho Jeong, Jun-Kyu Park
게제년월일 2019-08-20
ISSN 1225-0112
Impact Factor 4.978
학술지명 Applied Chemistry for Engineering
서지사항 0집 / 30권 / 5호,   페이지(586 - 590)
요약초록문
(Abstract) 입력		 The aim of this study was to fabricate a dextran polyelectrolyte multi-layer on a bare metal stent (BMS) and to evaluate bio-physical properties of the layer. Diethylaminoethyl-dextran (DEAE-D) as a polycation and dextran sulfate (DS) as a polyanion were successively coated on the bare metal stent by a well-known layer-by-layer procedure. The morphology of the stent surface and its cell adhesion were studied after each coating step by scanning electron microscopy. The stent showed more blotched and slightly rougher morphology after dextran-DS coating. The contact angle of the DEAE-DS group (39.5 ± 0.15°) was significantly higher than that of the BMS group (45.16 ± 0.08°), indicating the improvement of hydrophilic.
The SMC proliferation inhibition in the DEAE-DS-coated stent group (20.9 ± 0.04%) was stronger than that in the control group (21.7 ± 0.10% in DS-coated group only). The DEAE-DS coating is desired for stent coating materials with biocompatibility and anti-restenosis effect.
파일  B100. Fabrication and evaluation of polyectrolyte complexes of dextran derivatives for drug coating of coronary stents..pdf (1,010.2K) DATE : 2021-05-27 16:14:40