비임상

HOME > 연구실적 > 비임상 > 논문
 
작성일 : 21-05-27 17:20
논문번호 105
논문제목(영문) Anti-restenotic and anti-thrombotic effect of polymer-free N-TiO2 film-based tacrolimus-eluting stent in a porcine model
국내외구분 국외 SCI여부 SCI
연구책임자역할 교신저자
주저자명 Dae Sung Park
교신저자명 Myung Ho Jeong
공동저자명 ,In-Ho Bae,Myung Ho Jeong,Kyung-Seob Lim,Young Joon Hong,Jae Won Shim,Jae Un Kim,Mun Ki Kim,Jung Ha Kim,Dae Young Hyun,Jun-Kyu Park,Han Chul Lim ,Han Byul Kim,In-Soo Kim,Doo Sun Sim
게제년월일 2020-03-22
ISSN 2352-4928.
Impact Factor 2.678
학술지명 materials today communications
서지사항 0집 / 22권 / 0호,   페이지(0 - 0)
요약초록문
(Abstract) 입력		 A polymer-based coronary drug-eluting stent might induce inflammation and stent thrombosis of the vessel wall due to the presence of the polymer. Therefore, the purpose of this study was to compare synthetic poly lactic–glycolic acid (PLGA)-based tacrolimus (TCL)-eluting stents (PLGA-TES) and polymer-free TCL-eluting stents (PF-TES) in in vitro and in vivo models. The PF-TES was deposited with a TiO2 thin film onto a bare metal stent(BMS) using plasma-enhanced chemical vapor deposition (PECVD). The surface morphologies of the stents were investigated by scanning electron microscopy and energy dispersive X-ray spectroscopy methods. The effect of the drugs released from the stents on smooth muscle cell (SMC) proliferation and platelet adhesion were examined. Animal studies were performed with four study groups; 1) BMS, 2) N-TiO2, 3) PLGA-TES, and 4) PF-TES. Further, after 4 weeks of implantation, the vessels surrounding the stents were isolated and then subjected to various analyses. In this study, the stent was deposited with a very thin and uniform TiO2 film. The platelet adhesion on the TiO2 surfaces was less than that on the BMS surface. The drug was uniformly coated on the stent surface with a concentration of 1.184 μg/mm2
. SMC proliferation was significantly inhibited in the TCL-eluting stent group (62.8 %, 42.3 %, n = 7, p < 0.05, respectively). In the animal study, the percent area restenosis was significantly decreased in the PF-TES group compared with that in the BMS group (BMS: 41.1 ± 11.27 % vs. PFTES: 22.3 ± 7.02 % n = 10, p < 0.05). In particular, the fibrin score was lower in PF-TES group compared with that in the PLGA-TES group (PF: 1.3 ± 0.27 vs. PLGA-TES: 1.9 ± 0.53, n = 10, p < 0.05). The introduction of TiO2 deposition during fabrication of PF-TES might be an efficient process to prevent in-stent restenosis and thrombosis
파일  B105. Anti-restenotic and anti-thrombotic effect of polymer-free N-TiO2 film-based tacrolimus-eluting stent in a porcine model.pdf (4.6M) DATE : 2021-05-27 17:20:06