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작성일 : 21-05-28 10:39
논문번호 107
논문제목(영문) Comparison between Basic and Inverse Dual Drug and Peptide-coated Stents in a Porcine Restenosis Model
국내외구분 국내 SCI여부 SCI(E)
연구책임자역할 교신저자
주저자명 Eun-Jae Jang
교신저자명 Myung Ho Jeong
공동저자명 Eun-Jae Jang, So-Youn Lee, In-Ho Bae, Dae Sung Park, Myung Ho Jeong, Jun-Kyu Park
게제년월일 2020-08-20
ISSN 2576-3954
Impact Factor 0.345
학술지명 Journal of Chemistry and Applied Chemical Engineering
서지사항 0집 / 31권 / 5호,   페이지(502 - 508)
요약초록문
(Abstract) 입력		 Dual drug-eluting stents (DES) is a primary treatment method for coronary arterial diseases in current interventional cardiology practice. However, their pathological results according to the sequence of coating of drugs have not been reported yet. The peptide-dopamine dissolved in acetonitrile was coated onto the Chonnam National University Hospital (CNUH) stent using an electrospinning coating machine. For secondary coating (e.g., sirolimus coating, designated as SPS), sirolimus (SRL) and poly lactic-glycolic acid (PLGA) were mixed in tetrahydrofuran (THF), and the solution was then coated on the CNUH stent that had underwent
the primary peptide coating using an electrospinning and spray technique. Next, the peptide-dopamine was coated on the SRL-PLGA coated stent (PSS). In this study, it was confirmed that endothelialization was prooted without being significantly affected by the coating order (SPS or PSS). The sequence of drug and peptide coating may affect the development of restenosis and PSS was effective in the prevention of restenosis compared to that of using SPS.
파일  B107. Comparison between Basic and Inverse Dual Drug and Peptide-coated Stents~.pdf (2.8M) DATE : 2021-05-28 10:39:02