비임상

HOME > 연구실적 > 비임상 > 논문
 
작성일 : 23-07-19 08:59
논문번호 112
논문제목(영문) Preclinical Evaluation of a Novel Polymer-Free Everolimus-Eluting Stents in Mid-term Porcine Coronary Restenosis Model.
국내외구분 국내 SCI여부 SCI(E)
연구책임자역할 교신저자
주저자명 Cho KH
교신저자명 Jeong MH
공동저자명 Cho KH, Jeong MH, Park DS, Kim M, Kim J, Park JK, Han X, Hyun DY, Kim MC, Sim DS, Hong YJ, Kim JH, Ahn Y
게제년월일 2021-10-18
ISSN 1011-8934
Impact Factor 4.5
학술지명 JOURNAL OF KOREAN MEDICAL SCIENCE
서지사항 0집 / 36권 / 40호,   페이지(e259 - e259)
요약초록문
(Abstract) 입력		 Background: Titanium dioxide films exhibit good biocompatibility and may be effective as drug-binding matrices for drug-eluting stents. We conducted a mid-term evaluation of a novel polymer-free everolimus-eluting stent using nitrogen-doped titanium dioxide film deposition (TIGEREVOLUTION (R)) in comparison with a commercial durable polymer everolimus-eluting stent (XIENCE Alpine (R)) in a porcine coronary restenosis model.

Methods: Twenty-eight coronary arteries from 14 mini-pigs were randomly allocated to TIGEREVOLUTION (R) stent and XIENCE Alpine (R) stent groups. The stents were implanted in the coronary artery at a 1.1-1.2:1 stent-to-artery ratio. Eleven stented coronary arteries in each group were finally analyzed using coronary angiography, optical coherence tomography, and histopathologic evaluation 6 months after stenting.

Results: Quantitative coronary analysis showed no significant differences in the pre procedural, post-procedural, and 6-month lumen diameters between the groups. In the volumetric analysis of optical coherence tomography at 6 months, no significant differences were observed in stent volume, lumen volume, and percent area stenosis between the groups. There were no significant differences in injury score, inflammation score, or fibrin score between the groups, although the fibrin score was zero in the TIGEREVOLUTION (R) stent group (0 vs. 0.07 +/- 0.11, P = 0.180).

Conclusion: Preclinical evaluation, including optical coherence tomographic findings 6 months after stenting, demonstrated that the TIGEREVOLUTION (R) stent exhibited efficacy and safety comparable with the XIENCE Alpine (R) stent, supporting the need for further clinical studies on the TIGEREVOLUTION (R) stent.
파일  B.112.pdf (9.5M) DATE : 2023-07-19 08:59:26