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논문번호 9
논문제목(영문) The inhibitory effect of platelet glycoprotein IIb/IIIa receptor blocker-coated stent on porcine coronary stent restenosis.
국내외구분 국내 SCI여부 KCI
연구책임자역할 교신저자
주저자명 Kang K
교신저자명 Jeong MH
공동저자명 Kang KT, Jeong MH, Kim NH, Rhew JY, Lee SH, Park JC, Lee SU, Kim KH, Choi MJ. Ahn Y, Cho JG, Park JC, Choi WJ, Cho DL, Kang JC;
게제년월일 2000-11-29
ISSN 1738-9364
Impact Factor 0
학술지명 The Korean Journal of Medicine
서지사항 0집 / 60권 / 4호,   페이지(314 - 323)
요약초록문
(Abstract) 입력		 Background : The problems of coronary stent thrombosis and restenosis still remain to be solved. The glycoprotein IIb/ IIIa receptor blocker, Abciximab (ReoPro), plays important roles in the treatment of high- risk patient with acute platelet - rich thrombus and in the inhibition of smooth muscle cell proliferation. The aim of this study was to determine whether the use of ReoPro- coated stents could reduce the neointimal formation in a porcine coronary stent restenosis model.
Methods : ReoPro was coated on the surface of stent by means of plasma polymerization followed by chemical grafting . Stent overdilation injury was performed with control bare stent (Group I, n=13), and ReoPro- coated stents (Group II, n=14). Follow- up quantitative coronary angiogram was performed at 4 weeks after stenting and histopathologic assessment were compared in both groups.
Results : The diameter stenosis by QCA between two groups was significantly higher in Group I (23±5 % vs. 15±7 %, p =0.003). On histopathologic examination, no in- stent thrombus was observed. The percent area stenosis was significantly higher in Group I than in Group II (48±17 % vs. 30±16 %, p =0.01). The area of neoinima was larger in Group I than in Group II (3.2±1.2 mm2 vs. 2.0±1.0 mm2 , p =0.01). By immunocytochemistry, proliferation cell nuclear antigen indices were higher in Group I (4.2±2.1 %, vs 2.4±1.8 % p =0.03).
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