임상

HOME > 연구실적 > 임상 > 논문
 
작성일 : 16-03-14 01:12
논문번호 115
논문제목(영문) High plasma interleukin-6 is associated with drug-eluting stent thrombosis: possible role of inflammatory cytokines in the development of stent thrombosis from the Korea Stent Thrombosis Registry.
국내외구분 국외 SCI여부 SCI(E)
연구책임자역할 공저자
주저자명 Hwang SJ, Park KW
교신저자명 Kim HS
공동저자명 Hwang SJ, Park KW, Kwon DA, Kang HJ, Koo BK, Chae IH, Gwon HC, Park SJ, Seung KB, Ahn T, Yoon JH, Jang YS, Jeong MH, Tahk SJ, Kim HS;
게제년월일 2011-01-24
ISSN 1346-9843
Impact Factor 3.940
학술지명 Circulation journal
서지사항 0집 / 75권 / 6호,   페이지(1350 - 1357)
요약초록문
(Abstract) 입력		 Abstract: BACKGROUND: Inflammation might contribute to the development of stent thrombosis (ST). The association between inflammatory cytokine concentrations and drug-eluting ST were evaluated.
METHODS AND RESULTS: Among the 123 ST patients enrolled in the multicenter Korea Stent Thrombosis registry, plasma samples were available in 41 patients. The patients' clinical characteristics and plasma concentrations of monocyte chemoattractant protein-1, tumor necrosis factor-alpha, and interleukin (IL)-6 were compared with 81 matched controls. Although the concentrations of 3 cytokines were higher in the ST group, they did not have significant differences. When divided into quartiles, the proportion of patients with the highest quartile of IL-6 was higher in the ST group than in the control group (44% vs. 16%, P =0.001), and the highest IL-6 quartile was an independent predictor of ST for both early (adjusted hazard ratio [HR] 6.96; 95% confidence interval [CI] 1.75-27.66) and late ST (adjusted HR 4.71; 95%CI 1.06-20.92). In addition, the highest IL-6 quartile was an independent predictor of ST in those on clopidogrel (adjusted HR 7.70; 95%CI 1.97-30.13) but not in those who were off clopidogrel.
CONCLUSIONS: Highest IL-6 quartile was associated with ST, especially in
clopidogrel users regardless of the time of ST, suggesting the involvement of
inflammatory cytokines in ST.
파일  C115.+Circ+J.+2011;75(6)1350-1357..pdf (740.0K) DATE : 2021-05-25 15:20:30